Catalog Number - 68112-10P

Cogent RP C12™ is a unique reversed-phase UHPLC stationary phase featuring a rigid adamantane-like bonded phase on ultra-high purity silica. Fully double end capped and compatible with 100% aqueous mobile phases, it provides excellent retention stability, reproducible performance, and rapid re-equilibration between runs. With hydrophobic retention that is typically greater than C8 phases and lower than C18 phases, RP C12™ is an excellent choice for high-throughput screening, gradient methods, and complex mixture separations.

68112-10P is a UHPLC column packed with 1.8 µm RP C12™ particles with a 100 Å pore size in a 4.6 mm ID x 100 mm format. The 100 mm column length provides increased resolution and peak capacity compared to shorter 50 mm columns while maintaining efficient analysis times. The sub-2 µm particle technology delivers exceptional efficiency and chromatographic performance for demanding applications. Typical operating flow rates are approximately 1.0–2.0 mL/min depending on mobile phase composition, temperature, and instrument pressure limits.

This column is specifically engineered for UHPLC systems capable of operating at the elevated pressures generated by 1.8 µm particles. It is ideal for high-throughput screening, impurity profiling, pharmaceutical analysis, and complex sample separations where improved resolution and rapid equilibration are desired.

Key Benefits

• RP C12™ stationary phase

• Fully double end capped

• Adamantane-like bonded phase chemistry

• Compatible with 100% aqueous mobile phases

• Rapid re-equilibration between runs

• High-efficiency 1.8 µm particles

• Excellent for complex mixtures

• Increased peak capacity

• Improved chromatographic resolution

• Ideal for high-throughput screening

Typical Applications

• UHPLC analysis

• High-throughput screening (HTS)

• Pharmaceutical analysis

• Impurity profiling

• Complex mixture separations

• Gradient methods

• Quality control testing

• Stability studies

• Environmental analysis

• Research and development

Specifications

• Product Type: UHPLC Column

• Stationary Phase: RP C12™

• Chromatography Mode: Reversed Phase

• Bonded Phase: Adamantane-Like Carbon Silane

• Endcapping: Fully Double End Capped

• Particle Size: 1.8 µm

• Pore Size: 100 Å

• Column Dimensions: 4.6 mm ID x 100 mm

• Length: 100 mm

• Typical Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed specifically for UHPLC operation and high-pressure reversed-phase chromatography

• 1.8 µm particles generate substantially higher backpressure than conventional HPLC columns

• Maximum performance is achieved on UHPLC systems designed for sub-2 µm particle technology

• Compatible with 100% aqueous mobile phases without loss of retention

• The 100 mm length provides greater resolution and peak capacity than 50 mm columns

• Samples should be filtered through a 0.2 µm syringe filter prior to injection

• May be used on compatible HPLC systems only if instrument pressure limits are not exceeded

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